MOTS-c 10mg / 20mg / 40mg – Research Grade Lyophilized Peptide

🧪 Overview

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, encoded within the 12S rRNA region of mitochondrial DNA. It belongs to a class of peptides known as mitochondrial-derived peptides (MDPs), which are increasingly studied for their role in intracellular communication and metabolic regulation.

Unlike traditional peptides encoded by nuclear DNA, MOTS-c originates from the mitochondrial genome, making it a unique subject of study in cellular biology and metabolic signaling research. In laboratory environments, MOTS-c is investigated for its ability to influence nuclear gene expression and cellular adaptation under metabolic stress conditions.

Due to its distinct origin and signaling properties, MOTS-c has become a relevant compound in experimental models examining mitochondrial-to-nuclear communication and system-level metabolic regulation.

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🔬 Research Context & Mechanism

MOTS-c is studied for its role as a signaling peptide that can translocate from the mitochondria to the nucleus under conditions of metabolic stress. Once translocated, it has been observed to influence nuclear gene expression and regulate pathways associated with cellular homeostasis.

Research has demonstrated that MOTS-c participates in the regulation of metabolic processes through interaction with intracellular signaling systems. For example, studies have shown that MOTS-c can modulate pathways related to energy metabolism and cellular stress response.

In experimental models, this peptide has been shown to act as a regulator of metabolic balance, linking mitochondrial function with broader cellular signaling networks. This mechanism makes it particularly useful for studying how cells respond to environmental and metabolic challenges.

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🧬 Structural Characteristics

MOTS-c is a short peptide consisting of 16 amino acids, encoded directly within mitochondrial DNA rather than the nuclear genome. This structural origin distinguishes it from most other peptides used in laboratory research.

Key structural features include:

• Encoded by mitochondrial 12S rRNA
• Small molecular size (16 amino acids)
• Ability to translocate to the nucleus under stress conditions
• Participation in mitochondrial-nuclear signaling pathways

Because of its mitochondrial origin, MOTS-c is often used in studies investigating how mitochondrial signals influence cellular behavior at a systemic level.

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🧬 Pharmacological & Biochemical Profile

Within controlled laboratory environments, MOTS-c has demonstrated several characteristics relevant to research applications:

• Regulation of metabolic signaling pathways
• Interaction with nuclear gene expression mechanisms
• Involvement in cellular stress response systems
• Association with mitochondrial function and energy regulation

Research indicates that it plays a role in metabolic homeostasis and may influence insulin-related signaling pathways in experimental models.

Additional studies have shown that MOTS-c expression can increase in response to physical or metabolic stress, suggesting a role in adaptive cellular processes.

These properties make it a valuable compound for investigating how mitochondrial-derived signals contribute to overall cellular regulation.

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🧫 Experimental Applications

MOTS-c is commonly utilized in laboratory research involving:

• Mitochondrial signaling pathway analysis
• Metabolic regulation studies
• Cellular stress response modeling
• Gene expression and transcriptional regulation research
• Mitochondrial-nuclear communication studies

In vitro systems are frequently used to evaluate how the peptide influences cellular pathways under controlled conditions. Analytical techniques such as gene expression assays, metabolic profiling, and pathway mapping may be employed to assess its activity.

Because of its unique role as a mitochondrial-derived signaling peptide, this peptide is particularly useful in studies exploring the relationship between energy metabolism and cellular adaptation.

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📚 Scientific Reference

For further insight into the biological role of MOTS-c, refer to the following study:

👉 https://pubmed.ncbi.nlm.nih.gov/25738459/

This study describes MOTS-c as a mitochondrial-derived peptide that regulates metabolic homeostasis and cellular signaling in experimental models.

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🧊 Handling & Storage

MOTS-c is supplied as a lyophilized powder to maintain stability during storage and transport.

Recommended laboratory handling practices include:

• Storage at 2–8°C (36–46°F)
• Use of sterile laboratory techniques
• Reconstitution using analytical-grade solvents
• Avoidance of repeated freeze-thaw cycles

All preparation and handling should follow established laboratory protocols to ensure consistency and integrity in experimental applications.

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⚠️ Research Use Notice

MOTS-c is intended strictly for laboratory research and analytical purposes. It is not approved for human or veterinary use. All users are responsible for ensuring compliance with applicable regulations and proper handling procedures.